V2EX dutpase

DUTPase

释义 Definition

dUTPase(常写作 dUTPase,全称 deoxyuridine triphosphatase / dUTP nucleotidohydrolase)是一种核苷酸代谢酶,催化 dUTP(水解)→ dUMP + 焦磷酸(PPi)。它的关键作用是降低细胞内 dUTP 水平,从而减少尿嘧啶(uracil)被误掺入 DNA,帮助维持基因组稳定。 (en.wikipedia.org)

发音 Pronunciation (IPA)

/dijutipies/

例句 Examples

DUTPase helps prevent uracil from being incorporated into DNA.
dUTPase 有助于防止尿嘧啶被掺入 DNA。

Because the tumor had high dUTPase activity, the researchers considered targeting it to enhance the effect of fluoropyrimidine therapy.
由于该肿瘤的 dUTPase 活性较高,研究人员考虑靶向它以增强氟嘧啶类治疗的效果。 (cancer.gov)

词源 Etymology

该词由两部分构成:dUTPdeoxyuridine triphosphate,脱氧尿苷三磷酸)+ -ase(英语中常见的“酶”后缀)。字面意思就是“作用于 dUTP 的酶”。 (en.wikipedia.org)

相关词 Related Words

文学与文献作品 Notable Works

  • Crystal structure of a dUTPaseNature, 1992) 经典结构生物学论文,讨论 dUTPase 的三聚体结构与功能。 (nature.com)
  • Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPasesAccounts of Chemical Research, 2009) 系统综述 dUTPase 的生理作用、结构与催化机制。 (pubmed.ncbi.nlm.nih.gov)
  • Precluding uracil from DNAStructure, 1996) 迷你综述,聚焦避免尿嘧啶进入 DNA 的关键酶系统(含 dUTPase)。 (sciencedirect.com)
  • *Structural dynamics of human … (dUTPase)*(Scientific Reports, 2024) 研究人类 dUTPase 的结构动力学与潜在药物靶点意义。 (nature.com)
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